There is general acknowledgement that both the anterior cingulate and orbitofrontal cortex are implicated in reinforcement-guided decision making, and emotion and social behaviour. Despite the interest that these areas generate in both the cognitive neuroscience laboratory and the psychiatric clinic, ideas about the distinctive contributions made by each have only recently begun to emerge. This reflects an increasing understanding of the component processes that underlie reinforcement- guided decision making, such as the representation of reinforcement expectations, the exploration, updating and representation (...) of action values, and the appreciation that choices are guided not just by the prospect of reward but also by the costs that action entails. Evidence is emerging to suggest that the anterior cingulate and orbitofrontal cortex make distinct contributions to each of these aspects of decision making. (shrink)

The question concerning the meaning of life is important, but it immediately confronts the present authors with insurmountable obstacles from a philosophical standpoint, as it would require us to define not only what we hold to be life, but what we hold to be meaning in addition, requiring us to do both in a properly researched context. We unconditionally surrender to that challenge. Instead, we offer a vernacular, armchair approach to life’s origin and meaning, with some layman’s thoughts on the (...) meaning of origins as viewed from the biologist’s standpoint. One can observe that biologists generally approach the concept of biological meaning in the context of evolution. This is the basis for the broad resonance behind Dobzhansky’s appraisal that “Nothing in biology makes sense except in the light of evolution”. Biologists try to understand living things in the historical context of how they arose, without giving much thought to the definition of what life or living things are, which for a biologist is usually not an interesting question in the practical context of daily dealings with organisms. Do humans generally understand life’s meaning in the context of history? If we consider the problem of life’s origin, the question of what constitutes a living thing becomes somewhat more acute for the biologist, though not more answerable, because it is inescapable that there was a time when there were no organisms on Earth, followed by a time when there were, the latter time having persisted in continuity to the present. This raises the question of where, in that transition, chemicals on Earth became alive, requiring, in turn, a set of premises for how life arose in order to conceptualize the problem in relation to organisms we know today, including ourselves, which brings us to the point of this paper: In the same way that cultural narratives for origins always start with a setting, scientific narratives for origins also always start with a setting, a place on Earth or elsewhere where we can imagine what happened for the sake of structuring both the problem and the narrative for its solution. This raises the question of whether scientific origins settings convey meaning to humans in that they suggest to us from what kind of place and what kinds of chemicals we are descended, that is, to which inanimate things we are most closely related. (shrink)

Friedmann–Robertson–Walker (FRW) space–time with bulk viscosity in the context of f(R) gravity is considered. The field equations are solved for the Power and Exponential volumetric expansion. Two types of functional relationship i.e. f(R) = R + bRm and f(R)=R-λ4R\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ \,f(R) = R - \frac{{\lambda^{4} }}{R} $$\end{document} are investigated. The Phantom, Chaplygin gas and Tachyon fields are discussed. It is observed that the universe is open and inflationary.

Throughout his life, John Tyler Bonner contributed to major transformations in the fields of developmental and evolutionary biology. He pondered the evolution of complexity and the significance of randomness in evolution, and was instrumental in the formation of evolutionary developmental biology. His contributions were vast, ranging from highly technical scientific articles to numerous books written for a broad audience. This historical vignette gathers reflections by several prominent researchers on the greatness of John Bonner and the implications of his work.

Comparative study on Śaṅkarācārya and F.H. (Francis Herbert) Bradley, 1846-1924.

We introduce a linear analogue of Läuchli's semantics for intuitionistic logic. In fact, our result is a strengthening of Läuchli's work to the level of proofs, rather than provability. This is obtained by considering continuous actions of the additive group of integers on a category of topological vector spaces. The semantics, based on functorial polymorphism, consists of dinatural transformations which are equivariant with respect to all such actions. Such dinatural transformations are called uniform. To any sequent in Multiplicative Linear Logic (...) , we associate a vector space of“diadditive” uniform transformations. We then show that this space is generated by denotations of cut-free proofs of the sequent in the theory MLL + MIX. Thus we obtain a full completeness theorem in the sense of Abramsky and Jagadeesan, although our result differs from theirs in the use of dinatural transformations.As corollaries, we show that these dinatural transformations compose, and obtain a conservativity result: diadditive dinatural transformations which are uniform with respect to actions of the additive group of integers are also uniform with respect to the actions of arbitrary cocommutative Hopf algebras. Finally, we discuss several possible extensions of this work to noncommutative logic.It is well known that the intuitionistic version of Läuchli's semantics is a special case of the theory of logical relations, due to Plotkin and Statman. Thus, our work can also be viewed as a first step towards developing a theory of logical relations for linear logic and concurrency. (shrink)

The relations between physical science and technology, and their implications for culture, are investigated. Van Melsen argues that physical science merely extends, though in an abstract manner, man's ordinary methods of gaining knowledge about the world, that science and technology require one another, and that while science and technology threaten to overcome man's control of them, they also offer a great opportunity and stimulus to man's further self-realization.--K. P. F.

Objective To evaluate the modes of death and treatment offered in the last 24 h of life to patients dying in 10 Brazilian intensive care units (ICUs) over a period of 2 years. Design and setting Cross-sectional, multicentre, retrospective study based on medical chart review. The medical records of all patients that died in seven paediatric and three adult ICUs belonging to university and tertiary hospitals over a period of 2 years were included. Deaths in the first 24 h of (...) admission to the ICU and brain death were excluded. Intervention Two intensive care fellows of each ICU were trained in fulfilling a standard protocol (κ=0.9) to record demographic data and all medical management provided in the last 48 h of life. The Student t test, Mann–Whitney U test, χ2 test and RR were used for data comparison. Measurements and main results 1053 medical charts were included (59.4% adult patients). Life support limitation was more frequent in the adult group (86% vs 43.5%; p<0.001). A ‘do not resuscitate’ order was the most common life support limitation in both groups (75% and 66%), whereas withholding/withdrawing were more frequent in the paediatric group (33.9% vs 24.9%; p=0.02). The life support limitation was rarely reported in the medical chart in both groups (52.6% and 33.7%) with scarce family involvement in the decision making process (23.0% vs 8.7%; p<0.001). Conclusion Life support limitation decision making in Brazilian ICUs is predominantly centred on the medical perspective with scarce participation of the family, and consequently several non-coherent medical interventions are observed in patients with life support limitation. (shrink)